PROCESS FOR PREPARING N-ALKENYL-3-HYDROXYBENXO (B) THIOPHONE-2-CARBOXAMIDE DERIVATIVES

Benzothiophene (I) [R=hydrogen, lower alkyl, aryl, lower cycloalkyl, halo lower alkyl, hetero aryl, benzyl, lower alkenyl, lower alkynyl; n=0,1,2; X1,X2,X3,X4=R ; R1,R2,R3 = R, halo; R4=R, -CR1=CR2R3 is prepd. for use as an inibitor of lipoxygenase and cyclooxygenase. Compds. (II) is reacted with al...

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Bibliographic Details
Main Authors GALLAGHER TIMOTHY F, TISHLER ALLAN N, GOLDENBERG MARVIN M, WITZEL BRUCE D, DURETTE PHILIPPE L, RUPPRECHT KATHLEEN M
Format Patent
LanguageEnglish
Korean
Published 25.02.1987
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Benzothiophene (I) [R=hydrogen, lower alkyl, aryl, lower cycloalkyl, halo lower alkyl, hetero aryl, benzyl, lower alkenyl, lower alkynyl; n=0,1,2; X1,X2,X3,X4=R ; R1,R2,R3 = R, halo; R4=R, -CR1=CR2R3 is prepd. for use as an inibitor of lipoxygenase and cyclooxygenase. Compds. (II) is reacted with alkylating agent in strong acidic condition to give the title compd. (I). The alkylating agent is R1COCHR2R3,HCOCHR2R3, R OCH=CR2R3 or R SCH=CR2R3 [R =C1-6 alkyl, phenyl, benzyl!.
Bibliography:Application Number: KR19850002176