PROCESS FOR PREPARING SORBINIL INTERMEDIATES AND PROCESS FOR THE CONVERSION THEREOF TO SORBINIL

The title compds. II [R-H, benzyloxycarbonyl; Y=OH, amino! were prepd. Thus, 6.9g S-b-fluoro-4-(benzyloxycarbonylamino) chroman-4- carboxylic acid in 100ml methanol was mixed with 0.5g 5%-Pd/c and then the resulting mixt. was treated with hydrogen at 4 atm for 2-3h. The catalyst was removed. The res...

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Bibliographic Details
Main Authors CUE JR.,BERKELY W, MOORE BERNARD S
Format Patent
LanguageEnglish
Korean
Published 23.02.1987
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The title compds. II [R-H, benzyloxycarbonyl; Y=OH, amino! were prepd. Thus, 6.9g S-b-fluoro-4-(benzyloxycarbonylamino) chroman-4- carboxylic acid in 100ml methanol was mixed with 0.5g 5%-Pd/c and then the resulting mixt. was treated with hydrogen at 4 atm for 2-3h. The catalyst was removed. The resulting soln. was concd. and treated with toluene to give 3.9g S-b-fluoro-4-aminochroman-4-carboxylic acid.
Bibliography:Application Number: KR19850006045