PROCESS FOR THE PREPARATION OF PHENYLALKYLAMINES

Compd. of the formula (I) [R1=OH, C1-3 alkanyl, amino gp. substd. by C2-4 alkoxycarbonyl, alkylamino, dialkylamino; R2,R3= halo, CF3, CN, NO2, H; R4=H, C1-3 alkyl; R5=H, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C7-10 aralkyl; A=CH2, CH2CH2, HOCH; B= CHR8(CH)2DC6H6(R6) (R7) or EC6H6(R6)(R7); R6=H,...

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Bibliographic Details
Main Authors DAEMMGEN JUERGEN, NOLL KLAUS, KRUEGER GERD, KECK JOHANNES, PIEPER HELMUT
Format Patent
LanguageEnglish
Korean
Published 14.02.1987
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
INFORMATION STORAGE
INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORDCARRIER AND TRANSDUCER
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compd. of the formula (I) [R1=OH, C1-3 alkanyl, amino gp. substd. by C2-4 alkoxycarbonyl, alkylamino, dialkylamino; R2,R3= halo, CF3, CN, NO2, H; R4=H, C1-3 alkyl; R5=H, C1-4 alkyl, C3-6 cycloalkyl, C2-5 alkenyl, C7-10 aralkyl; A=CH2, CH2CH2, HOCH; B= CHR8(CH)2DC6H6(R6) (R7) or EC6H6(R6)(R7); R6=H, halo, OH, C1-3 alkoxy, C1-3 alkyl, sulfenyl or alkylsulfynyl; R7=H, OH, C1-3 alkoxy; R6=R7=methylenedioxy; R8=H or C1-3 alkyl; D=O,S,SO3,SO4; E=C3-5 alkylene, etc! were prepd. Thus, 0.5g Na8H4 was treated with a soln. of 3.45g 4'-amino-3',5'-dichloro-2-[N-3-[(4-methoxyphenyl)- propyl!methylamino! acetophenone at pH of 3-6 to give 1(4-amino-3,5- dichlorophenyl)-2-[N-3-(4-methoxyphenyl)-propyl! methylamino!ethanol.
Bibliography:Application Number: KR19810004912