PROCESS FOR THE PREPARATION OF PEPTIDES

Peptides of formula I [X = H, C1-7 acyl; R1 = dehydro Pro, dehydro D- Pro, D- or L- Thz; R2 = D-Phe, D-His, D-Trp, Trp, D-Phe(Cl), D- Phe(Cl2), D-Phen(CF3), D-Phe(F), D-Phe(F2), etc.; R3 = D-Trp, Trp. D- Phe or D-His; R4 = Gly or D-amino acid residue; R5 = Leu, MeLeu; R6 = Gly-NH2, NHCH2CH3 were pre...

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Bibliographic Details
Main Authors RIVIER JEAN EDOUARD FREDERIC, RIVIER CATHERINE LAURE, VALE JR.WYLIE WALKER
Format Patent
LanguageEnglish
Korean
Published 16.08.1985
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Peptides of formula I [X = H, C1-7 acyl; R1 = dehydro Pro, dehydro D- Pro, D- or L- Thz; R2 = D-Phe, D-His, D-Trp, Trp, D-Phe(Cl), D- Phe(Cl2), D-Phen(CF3), D-Phe(F), D-Phe(F2), etc.; R3 = D-Trp, Trp. D- Phe or D-His; R4 = Gly or D-amino acid residue; R5 = Leu, MeLeu; R6 = Gly-NH2, NHCH2CH3 were prepd. using a solidphase method on a benzhydrylamine resin. The title compds. are used as inhibitors of pituitary gonadotropin release and of steroid release by gonads, esp. for ovulation inhibition.
Bibliography:Application Number: KR19810001129