PROCESS FOR THE PREPARATION OF 1-ARYLOXY-3-ALKYLAMINO-2-PROPANOLS

The title compds. I R1 = C1-20, n-, or branched alkyl; R2 = H, halo, C1-4, n- or branched alkyl, alkoxy, (CH2)n n = 3-5;R3 = C3-10 n- or branched alkyl! were prepd. Thus, 10g 1-(2-cyano- 4-hexanoilaminophenoxy)-2,3-epoxypropanol was dissolved in 1000 ml EtOH, and 8.3g isopropylamine was added. The m...

Full description

Saved in:
Bibliographic Details
Main Authors STAEHLE HELMUT, KUMMER WERNER, MUACEVIC GOJKO, KOEPPE HERBERT
Format Patent
LanguageEnglish
Korean
Published 22.10.1984
Edition3
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The title compds. I R1 = C1-20, n-, or branched alkyl; R2 = H, halo, C1-4, n- or branched alkyl, alkoxy, (CH2)n n = 3-5;R3 = C3-10 n- or branched alkyl! were prepd. Thus, 10g 1-(2-cyano- 4-hexanoilaminophenoxy)-2,3-epoxypropanol was dissolved in 1000 ml EtOH, and 8.3g isopropylamine was added. The mixt. was refluxed and recrystalized with acetonitryl for 1 hr. to give 3.8g I. I can be used in the treatment or prevention of coronary heart disease and angina.
Bibliography:Application Number: KR19810001406