PROCESS FOR PREPARING CEPHEM DERIVATIVES

Cephems I(R1=H, (un) substituted alkyl, acyl, arylsulfonyl, alkylsulfonyl, amino-protective group; R2=H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl, heterocycle; R3=H, esterforming group, cation; R4=H, alkoxy; A=H, (un) substituted alkoxy or...

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Bibliographic Details
Main Authors DURCKBEIMER WALTER, SELIGER HUBERT, EHLERS EBERHARD, SCHRINNER ELMAR
Format Patent
LanguageEnglish
Published 07.04.1983
Edition3
Subjects
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Summary:Cephems I(R1=H, (un) substituted alkyl, acyl, arylsulfonyl, alkylsulfonyl, amino-protective group; R2=H, (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl, heterocycle; R3=H, esterforming group, cation; R4=H, alkoxy; A=H, (un) substituted alkoxy or alkenoxy, halo, alkyl; X=S, O, CH2, NH), useful as antimicrobial agents were prepd. I(R=R3=R4=H; R1=Me, Et; R2=H, Na; X=S) are esp. effective against Pseudomonas. E.g., dicyclohexylcarbodiimide-midiated coupling of 2-synmethoxyimino-2-(2tritylamino-4-thiazolyl) acetic acid with 7-aminoceph-3-em-4-carboxylic acid, followed by purifn. via the (H2NCH2)2 salt, gave I(R, R2-R4=H, R1=Me)
Bibliography:Application Number: KR19780001066