PROCESS FOR PREPARING 5-(4-PYRIDYL)-6-(4-FLUORO PHENYL)-2,3-DIHYDRO IMIDAZO-(2,1B)THIAZOLE

Title compd. (I), useful in the treatment of arthritis, was prepd. by the reaction of 4-(4-pyridyl)-5-(4-fluorophenyl)-2-mercaptoimidazole and 1,2-dihaloethane. Thus, 4-(4-pyridyl)-5-)4-fluorophenyl)-2-mercaptoimidazole was treated with 1-brome-2-chloroethane and NaH in DMF to give a mixt. of I, and...

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Bibliographic Details
Main Authors LANTOS IVAN, BENDER PAUL ELLIOT
Format Patent
LanguageEnglish
Published 06.04.1983
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Title compd. (I), useful in the treatment of arthritis, was prepd. by the reaction of 4-(4-pyridyl)-5-(4-fluorophenyl)-2-mercaptoimidazole and 1,2-dihaloethane. Thus, 4-(4-pyridyl)-5-)4-fluorophenyl)-2-mercaptoimidazole was treated with 1-brome-2-chloroethane and NaH in DMF to give a mixt. of I, and septed. by isopropanol/ether(1:2) to give I.
Bibliography:Application Number: KR19790003216