PROCESS FOR PREPARING THIENYL-PROSTAGLANDINS

Title compds. I(R1,R2 = H, OH; R3 = α- or β-thienyl, α- or β-thienylmethyl, benzo[b thiophene, cyclopentano[b thiopene, cyclohexano[b thiopene; X = C1-7 straight-or sidechain alkylene, C2-8 alkoxyalkylene), exhibiting a hypotension activity and a urination activity, were prepd. by the reaction of la...

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Bibliographic Details
Main Authors REUSCHLING DIETER, BECK GERHARD, SEEGAR KARL, BARTMANN WILHELM, TEUFEL HERMANN
Format Patent
LanguageEnglish
Published 23.02.1983
Subjects
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Summary:Title compds. I(R1,R2 = H, OH; R3 = α- or β-thienyl, α- or β-thienylmethyl, benzo[b thiophene, cyclopentano[b thiopene, cyclohexano[b thiopene; X = C1-7 straight-or sidechain alkylene, C2-8 alkoxyalkylene), exhibiting a hypotension activity and a urination activity, were prepd. by the reaction of lactol (II) and 4-carboxy-butyl-triphenylphosphonium bromide in NaH-dissolved dimethylsulfoxide in the presence of inert gas to give formula acid(II), which was acid hydrolyzed to give compds. I or their esters by eliminating tetrahydropyranyl protecting group.
Bibliography:Application Number: KR19760000522