PROCESS FOR PREPARING BENZENESULFONYL UREAS

Benzenesulfonyl ureas (I; X = pyridyl, pyrimidinyl, quinolyl, benzothiazolyl, benzoxazolyl; R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkenyl, cycloalkeny, bicycloheptyl, adamantyl, benzyl), useful as hyperglycemic agent, were prepd. by substituting S with O from II-substituted benzenesulfonylthiou...

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Bibliographic Details
Main Authors AUMUELLER W, BEYER R, HITSEL V, SCHMIDT F
Format Patent
LanguageEnglish
Published 04.06.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Benzenesulfonyl ureas (I; X = pyridyl, pyrimidinyl, quinolyl, benzothiazolyl, benzoxazolyl; R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkenyl, cycloalkeny, bicycloheptyl, adamantyl, benzyl), useful as hyperglycemic agent, were prepd. by substituting S with O from II-substituted benzenesulfonylthiourea. Thus, 5 g N-[4-(β-(N'-methyl-N'-pyridyl-ureido)-ethyl) benzenesulfonyl -N'-cyclohexyl-thiourea(4(β-<N'-methylN'-2-pyridyl-ureido)-ethyl)-benzenesulfonamide and cyclohexyl isocvanate were treated in acetone in the presence of potassium carbonate to give I
Bibliography:Application Number: KR19770003048