PROCESS FOR PREPARING BENZENESULFONYL UREAS

Title compds.(I, R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkyl, alkylcycloalky, cycloalkenyl, bicyclohetyl, bicycloheptenyl, nortricyclyl, benzyl), useful for lowering the blood sugar concentration, were prepd. by reaction of compds. II(Z =halogen, hydroxy, o-alkali metal group) with III in the p...

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Bibliographic Details
Main Authors AUMUELLER W, BEYER R, HITSEL V
Format Patent
LanguageEnglish
Published 29.05.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Title compds.(I, R = C1-3 alkyl; R1 = C3-6 alkyl, C5-9 cycloalkyl, alkylcycloalky, cycloalkenyl, bicyclohetyl, bicycloheptenyl, nortricyclyl, benzyl), useful for lowering the blood sugar concentration, were prepd. by reaction of compds. II(Z =halogen, hydroxy, o-alkali metal group) with III in the presence of acid-condensation agent. Thus, N- 4-(β-N'-methyl-N'-2-pyridylureidoethyl)-benzenesulfonyl -N'-cyclohexylurea was prepd. by reacting 3.2 g 4-(β-N'methyl-N'-pyridyl -ureidoethyl_-benzenesulfinic acid with 1.6 g N-cyclohexyl-N'-hydroxyurea in 40ml dioxane at 60 C for 2hrs.
Bibliography:Application Number: KR19770003053