BENZENSULFONYL-UREAS AND THEIR PREPARATION

Benzenesulfonylureas (I; X = 2-quinolyl, 4-methyl-2-quinoyl, 2-pyridyl, R = Me, Et, Pr, R1 = alkyl, cycloalkyl, cycloalkylmethyl, Benzyl) were prepd. by heating 5.6g 4-(β-N'- 2-quinolyl-N'-methylureidoethyl)-benzenesulfonylmethylcarbamate and a mixt. of 1.lg cyclopentylamine and 75ml dioxa...

Full description

Saved in:
Bibliographic Details
Main Authors AUMUELLER W, WEYER R, HITZEL V
Format Patent
LanguageEnglish
Published 26.03.1979
Online AccessGet full text

Cover

More Information
Summary:Benzenesulfonylureas (I; X = 2-quinolyl, 4-methyl-2-quinoyl, 2-pyridyl, R = Me, Et, Pr, R1 = alkyl, cycloalkyl, cycloalkylmethyl, Benzyl) were prepd. by heating 5.6g 4-(β-N'- 2-quinolyl-N'-methylureidoethyl)-benzenesulfonylmethylcarbamate and a mixt. of 1.lg cyclopentylamine and 75ml dioxane. When I was administered orally to rabbits at 10mg/kg, the blood sugar level was decreased by 4.3% after one hr, 49% after 24hr, and 18% after 47hr.
Bibliography:Application Number: KR19730001284