조작된 면역 세포 플랫폼

• Main Author: DE LA ROCHE MAIKE
• Format: Patent
• Language: Korean
• Published: 18.11.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 조작된 면역 세포를 제공하며, 여기서 조작된 면역 세포는 Cav 채널에 기능 획득 돌연변이를 포함하고/하거나 L형 전압 개폐형 칼슘(Cav) 채널을 과발현한다.　 또한, 의약에 사용하기 위한 관련 조작된 면역 세포도 제공된다.　 또한, 증식성 장애를 갖는 대상체에서 면역 세포의 세포 사멸 활성을 자극하는 방법에 사용하기 위한 L형 Cav 채널 작용제도 제공된다.　 약제학적 조성물 및 방법도 또한 제공된다. The invention provides an engineered immune cell, wherein the engineered immune cell comprises a gain-of-function mutation in a Cav channel and/or overexpresses an L-type voltage-gated calcium (Cav) channel. Also provided are related engineered immune cells for use in medicine. Also provided are L-type Cav channel agonists for use in a method of stimulating cell killing activity of an immune cell in a subject having a proliferative disorder. Pharmaceutical compositions and methods are also provided.