압출된 안구 삽입물 또는 이식물 및 이들의 방법

• Main Authors: JARRETT TIMOTHY S, EL HAYEK RAMI, JARRETT PETER, HASWANI DINESH, DICKINSON ERIC, KAHN ERICA, MCGRATH MICHAEL
• Format: Patent
• Language: Korean
• Published: 06.08.2024
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS; MEDICAL OR VETERINARY SCIENCE; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCESIN A PLASTIC STATE; PROSTHESES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRANSPORTING; TREATMENT OR PROTECTION OF EYES OR EARS; WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL

본원 발명은 신체 투여 예를 들면, 안구 투여에 적합한 삽입물 또는 이식물을 형성하기 위해 중합체 조성물 및 활성제를 용융 압출 또는 사출 성형하는 단계를 포함하는, 지속 방출형 생분해성 안구 삽입물 또는 이식물을 제조하는 방법에 관한 것이다. 이 방법은 중합체 조성물 및 활성제를 압출기에 공급하는 단계; 압출기에서 성분을 혼합하는 단계; 가닥을 압출하는 단계; 및 가닥을 단위 용량 삽입물 또는 이식물로 절단하는 단계를 포함한다. The present invention is directed to a method of preparing a sustained release biodegradable ocular insert or implant comprising melt extruding or injection molding a polymer composition and an active agent to form an insert or implant suitable for administration to the body. e.g., ocular administration. The method comprises feeding the polymer composition and the active into an extruder; mixing the components in the extruder; extruding a strand; and cutting the strand into unit dose inserts or implants.