뉴클레오시드류 화합물의 결정형

• Main Authors: ZHOU QIFAN, LI GUANGUAN, LI SHUO, LIU XINJUN, LI YINGJUN
• Format: Patent
• Language: Korean
• Published: 25.07.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 일종의 뉴클레오시드류 화합물의 결정형을 제공하는데 상기 결정형은 ATV014 결정형 I이고 이는 양호한 용해성과 열안정성을 가지며 특정 제제에서 더 양호한 생체이용도 및 용출곡선을 가지고 그 양호한 삼투성과 열안정성은 특정된 약물제제 중에서 사용이 적합하다. Provided are a new crystal form of a nucleoside compound and a salt thereof, which belong to the technical field of medicines. The nucleoside compound is compound ATV014. Whether compound ATV014 exists in a variety of solid forms is emphatically investigated. Surprisingly, it is found that compound ATV014 exists in a variety of stable solid forms, comprising: ATV-014 free base crystal form I, ATV-014 hydrochloride crystal form I, ATV-014 hydrochloride crystal form II, ATV-014 hydrochloride crystal form III, ATV-014 hydrochloride crystal form IV, ATV-014 hydrobromide crystal form I, and ATV-014 p-toluenesulfonate crystal form I. The provided new crystal form of the compound ATV014 free base and the salt thereof has good solubility and thermal stability, has a better bioavailability and dissolution curve in a specific preparation and is suitable for use in a specific pharmaceutical preparation due to the good permeability and thermal stability thereof.