신규한 조성물

• Main Authors: MENDROK-EDINGER CHRISTINE, WILDERMANN ANGELA, HOUSTON PETER LOUIS, JACKSON EILEEN
• Format: Patent
• Language: Korean
• Published: 22.07.2024
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

본 발명은 0.03 미만의 시스/트랜스 비율을 갖는 레티닐 에스터, 특히 레티닐 아세테이트의 시스 및 트랜스 이성질체의 레티노이드 혼합물을 포함하는 신규한 조성물, 및 5-HT2B 세로토닌 수용체 길항제로 치료될 수 있는 질병 및 병태, 예컨대 비제한적으로 편두통, 불안, 저안압증, 심장판막증, 과민성 대장 증후군 및 MDMA(일반적으로 "엑스터시"라고 함) 남용으로부터 선택되는 질병 또는 병태의 치료, 예방 및 증상 완화를 위한 이의 용도에 관한 것이다. The present invention relates to novel compositions comprising a retinoid mixture of cis and trans isomers of a retinyl ester, particularly retinyl acetate, with a cis/trans ratio of less than 0.03 as well as the use thereof for the treatment, prevention and lessening of the symptoms of diseases and conditions which can be treated with 5-HT2B serotonin receptor antagonists, including but not limited to diseases or conditions selected from migraine headaches, anxiety, ocular hypotension, heart valve disease, irritable bowel syndrome, and MDMA (commonly called "ecstasy") abuse.