3 Cross-linkable Polymers for Fabrication of Biodegradable 3D Hydrogel Scaffold and Process Thereof

• Main Authors: HAIT SAMIK KUMAR, GAJENDRAN MANI, RAMAKUMAR SANKARA SRI VENKATA, OTA JYOTIRANJAN
• Format: Patent
• Language: English; Korean
• Published: 16.07.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; GENERAL PROCESSES OF COMPOUNDING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; WORKING-UP

본 발명은, 생분해성 3차원 복합 하이드로겔 스케폴더 및 가교성 합성 생분해성 폴리머, 메타크릴화 폴리 멀티카르복실산-폴리에틸렌글리콜(ma-pmca-peg) 및 변형된 천연 폴리머 말레산염 젤라틴(gel-mea)으로부터 이를 제조하는 방법에 관한 것이다. 본 발명은 간단하고 비용-효율적인 방법을 통해 가교성 합성 및 천연 폴리머를 개발하는 방법을 다룬다. 멀티카르복실산-b-폴리에틸렌 글리콜(pmca-peg)이 직접 용융 중축합 기술로 합성된 후, 우수한 가교성을 갖는 생분해성 신소재인 가교성 ma-pmca-peg를 제조하기 위해 글리시딜 메타크릴레이트를 사용하여 메타크릴레이트화된다. 천연 폴리머 젤라틴(gel)은, 가교성 gel-mea를 얻기 위해 말레산 무수물(mea)과 반응된다. The present invention relates a biodegradable 3D composite hydrogel scaffold and a process for preparing the same from a cross-linkable synthetic biodegradable polymer, methacrylated poly multi-carboxylic acid-polyethylene glycol (MA-PMCA-PEG) and a modified natural polymer maleated gelatin (GEL-MEA). The invention deals with development of cross-linkable synthetic and natural polymers from simple and cost-effective methods. A multicarboxylic acid-b-polyethylene glycol (PMCA-PEG), is synthesized by a direct melt polycondensation technique and thereafter methacrylated using glycidyl methacrylate to prepare cross-linkable MA-PMCA-PEG, which is a new biodegradable material with excellent cross-linking properties. The natural polymer gelatin (GEL) is reacted with maleic anhydride (MEA) to get cross-linkable GEL-MEA.