METHODS FOR TREATING AND/OR PREVENTING GRAFT-VERSUS-HOST DISEASE AND/OR DIFFUSE ALVEOLAR HEMORRHAGE AND/OR VENO-OCCLUSIVE DISEASE ASSOCIATED WITH HEMATOPOIETIC STEM CELL TRANSPLANT

• Main Authors: DUDLER THOMAS, DEMOPULOS GREGORY A, SCHWAEBLE HANS WILHELM
• Format: Patent
• Language: English; Korean
• Published: 05.07.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

한 측면으로, 발명은 조혈 줄기 세포 이식과 관련된 이식편대숙주병 및/또는 미만성 폐포 출혈 및/또는 정맥 폐쇄 질환을 앓고 있는 인간 대상체에서 MASP-2-의존성 보체 활성화의 효과를 억제하는 방법을 제공한다. 방법은 MASP-2-의존성 보체 활성화를 억제하기에 효과적인 양의 MASP-2 억제제를 그것을 필요로 하는 대상체에게 투여하는 단계를 포함한다. In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a human subject suffering from graft-versus-host disease and/or diffuse alveolar hemorrhage and/or veno-occlusive disease associated with a hematopoietic stem cell transplant. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.