MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

• Main Authors: PELLETIER GUILLAUME, KOEHLER MICHAEL FRIEDRICH THOMAS, SOW BOUBACAR, WINTER DANA, STURINO CLAUDIO, SMITH PETER ANDREW, BOUDREAULT JONATHAN
• Format: Patent
• Language: English; Korean
• Published: 02.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본원은 항균 화합물을 제공하며 일부 구현예에서는 화합물이 광범위 스펙트럼의 생물활성을 갖는다. 다양한 구현예에서, 상기 화합물들은 박테리아 내의 필수 단백질인 박테리아 유형 1 신호 펩티다제 SpsB 및/또는 LepB의 억제에 의해 작용한다. 또한, 본 명세서에 서술된 화합물을 사용한 치료용 약제학적 조성물 및 방법이 제공된다. Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.