Pharmaceutical composition for improving immunity reinforcement or anti-cancer activity comprising an extract of Veronica nakaianum as an active ingredient

• Main Authors: KIM WON KYU, BAEK JONG GWON, JANG DAE SIK, PARK IN WHA, LEE HYEON SEONG, KWON HAK CHEOL, SONG SUNG MIN, LEE CHOONG GU, KWON YU JIN, HWANG HO SEONG, LEE SOON KWANG, CHO SU YEON, KIM DONG HOON, KWON JAE YOUNG
• Format: Patent
• Language: English; Korean
• Published: 28.06.2024
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

본 발명은 섬꼬리풀로부터 분리된 화합물에서 Th17로의 분화 및 그 활성 증가 기능과 Treg로의 분화 및 그 활성 억제 기능을 확인하여 완성된 것으로서, 본 발명의 조성물은 Th17 및 Treg 세포 집단과 그 활성을 동시에 조절하여 면역반응을 증가시키는바, 암 및 감염병의 예방 및 치료를 위해 적용될 수 있다. 본 발명은 오랫동안 높은 안전성이 검증된 천연물인 섬꼬리풀을 이용하여 사용에 따른 부작용이 매우 적거나 없다는 장점을 가진다. 이에, 본 발명은 면역증진과 감염병 및 종양의 개선, 예방, 또는 치료를 위한 의약용, 의약부외용, 향장소재용, 기능성 바이오 소재용 및 기능성 식품소재용 등 다양한 방면으로 이용될 것으로 기대된다. The present disclosure is completed by confirming the differentiation into Th17 and its activity-increasing function and the differentiation into Treg and its activity-suppressing function in compounds isolated from Pseudolysimachion nakaianum (Ohwi) T. Yamaz. The composition of the present disclosure increases the immune response by simultaneously regulating Th17 and Treg cell groups and their activities, and thus may be applied for the prevention and treatment of cancer and infectious diseases. According to the present disclosure, there is an advantage of having very few or no side effects by using Pseudolysimachion nakaianum (Ohwi) T. Yamaz, a natural product with safety that has been verified for a long time. Therefore, the present disclosure is expected to be used in various fields such as drugs, quasi-drugs, cosmetic materials, functional biomaterials, and functional food materials for immunity reinforcement and improvement, prevention, or treatment of infectious diseases and tumors.