A Method for Differentiating Natural Killer Cells from Stem Cells and Uses Thereof

• Main Authors: JANG SEIL, SHIN HYUN YOUNG, LIM YU JIN, KIM WOON HAE, HABIB OMER, LEE JUNG MIN, KIM JOO YOUNG, KIM DONG OH
• Format: Patent
• Language: English; Korean
• Published: 30.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

본 발명은 미분화 줄기세포로부터 자연 살해 세포로의 분화 방법 및 이의 용도에 관한 것으로, 본 발명의 NK 세포 분화 방법은 전분화능 줄기세포로부터 NK 세포로의 분화를 유도함으로써 고순도의 높은 살상력을 갖는 NK 세포를 효과적으로 단기간에 수득할 수 있으므로 목적 질환의 세포치료제로 제공하는 데 유용하게 이용될 수 있다. The present invention relates to a method for differentiation from undifferentiated stem cells into natural killer cells and use thereof. In the method for differentiation into NK cells of the present invention, by inducing differentiation from pluripotent stem cells into NK cells, high-purity NK cells having high killing power can be effectively obtained in a short period of time, and thus can be effectively used to provide a cell therapeutic agent for a target disease.