10--4--899A10--7H-[1'2':45][12-B]-35- 10-diphenylmethyl-4-hydroxy-899A10-tetrahydro-7H-pyrollo[1'2':45]pyrazino[12-B]pyridazine-35-dione derivative as the inhibitor of the orthomyxovirus reproduction for the treatment of influenza and related compound

본 개시내용은 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7H-피롤로[1';2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 화학식 (A)의 관련 화합물에 관한 것이다. 바람직한 구체적 화합물은 예를 들어 (9aR, 10S)-10-((S)-(4-플루오로페닐)(3-(트리플루오로메틸)페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7H-피롤로[1';2':4,5]피라지노[1,2-b]피리다진-3,5...

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Bibliographic Details
Main Authors MANNING JAMES R, POON DANIEL, JAIN RAMA, MARX VANESSA, WAN LIFENG, WANG XIAOJING MICHAEL, DAUPHINAIS MAXIME, ZHAO QIAN, YIFRU AREGAHEGN, KOESTER DENNIS CHRISTOFER
Format Patent
LanguageEnglish
Korean
Published 24.05.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:본 개시내용은 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7H-피롤로[1';2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 화학식 (A)의 관련 화합물에 관한 것이다. 바람직한 구체적 화합물은 예를 들어 (9aR, 10S)-10-((S)-(4-플루오로페닐)(3-(트리플루오로메틸)페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7H-피롤로[1';2':4,5]피라지노[1,2-b]피리다진-3,5-디온 (실시예 1)이다. TIFFpat00122.tif3553 The invention provides compounds of Formula (I):as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.
Bibliography:Application Number: KR20247015694