5-옥소-피리도[2,3-d]피리다진-6(5H)-일 아세트아미드

• Main Authors: LEENAERTS JOSEPH ELISABETH, LAMKANFI MOHAMED, VAN GOOL MICHIEL LUC M, OEHLRICH DANIEL, MURATORE MICHAEL ERIC, PEREZ BENITO LAURA, TRESADERN GARY JOHN, VAN OPDENBOSCH NINA
• Format: Patent
• Language: Korean
• Published: 05.03.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 NLRP3 인플라마좀 생성의 억제제로서 사용하기 위한 신규한 화합물에 관한 것으로, 그러한 화합물은 화학식 (I)의 화합물로 정의된 바와 같으며, 상기 식에서 정수 R1, R2 및 R3은 상세한 설명에 정의되어 있으며; 상기 화합물은, 예를 들어 NLRP3 인플라마좀 활성과 관련된 질병 또는 장애의 치료에 사용하기 위한 약제로서 유용할 수 있다. JPEGpct00087.jpg2666 The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.