GRK5 조절제로서3-치환된 1H-피롤로[2,3-b]피리딘

• Main Authors: BAUMANN MATTHIAS, ZHANG JIANMIN, SCHULTZ FADEMRECHT CARSTEN, NUSSBAUMER PETER, KLEBL BERT, ENGEL JULIAN
• Format: Patent
• Language: Korean
• Published: 20.02.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 화학식 (I)의 특정 3-치환된 1H-피롤로[2,3-b]피리딘 화합물 및 이의 약제학적으로 허용가능한 염에 관한 것이다. 이러한 화합물은 심장 질환, 염증 및 면역 질환, 대사 질환 및 암 중에서 선택된 GRK5를 통해 매개되는 질병 또는 의학적 증상을 치료 또는 예방하는 데 유용하다. JPEGpct02640.jpg6587(I) The present invention relates to certain 3-substituted 1H-pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease or medical condition mediated through GRK5 selected from heart disease, inflammatory and immunological disease, metabolic disease and cancer.