Recombinant fusion protein for antigen delivery and uses thereof

• Main Authors: PARK JUN GYU, KIM YOUNGMOK, KIM HAN BYUL, CHO SEONG JE, KIM DAE HEE, SHIN DO WOON, MIN KYEONGSIK, RYU SU JEONG, JANG SUNG WOONG, KIM DA EUN
• Format: Patent
• Language: English; Korean
• Published: 07.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

T 세포 에피토프를 함유하는 펩티드 항원, 상기 펩티드 항원의 N-말단에 연결된 제1 캐리어 단백질, 및 상기 펩티드 항원의 C-말단에 연결된 제2 캐리어 단백질을 포함하는, 융합 단백질; 상기 융합 단백질을 코딩하는 핵산 분자; 상기 핵산 분자를 포함하는 발현 벡터; 상기 발현 벡터로 형질전환된 세포; 및 상기 융합단백질, 핵산 분자, 발현 벡터, 또는 세포를 포함하는 면역원성 조성물에 관한 것이다. The present invention relates to a fusion protein comprising a peptide antigen containing a T cell epitope, a first carrier protein linked to the N-terminus of the peptide antigen, and a second carrier protein linked to the C-terminus of the peptide antigen; a nucleic acid molecule encoding the fusion protein; an expression vector containing the nucleic acid molecule; a cell transformed with the expression vector; and an immunogenic composition comprising the fusion protein, the nucleic acid molecule, the expression vector, or the cell.