Runx3 K-Ras Pharmaceutical composition for preventing or treating of K-Ras mutated lung cancer comprising Runx3 gene or protein as an active ingredient

• Main Authors: LEE JA YEOL, LEE YOU SOUB, BAE SUK CHUL
• Format: Patent
• Language: English; Korean
• Published: 24.01.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

본 발명은 Runx3을 유효성분으로 함유하는 K-Ras 돌연변이 폐암의 예방 또는 치료용 약학 조성물에 관한 것이다. 구체적으로, 본 발명에서 제작한 Runx3 유전자가 결손되고 K-Ras 유전자가 활성화된 폐암 마우스에서 Runx3 유전자를 복구시키면 기존의 활성화된 암 유전자를 억제시키는 전략에 비해 폐암을 재발 가능성 없이 완전하게 치료할 수 있음을 확인한 바, 본 발명의 Runx3 단백질, 이를 암호화하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를 포함하는 벡터 또는 상기 벡터에 의해 형질전환된 바이러스 또는 세포를 유효성분으로 함유하는 조성물은 K-Ras 돌연변이 폐암의 예방 또는 치료용 조성물로 유용하게 사용될 수 있다. The present invention relates to a pharmaceutical composition comprising a Runx3 gene or protein as an active ingredient for prevention or treatment of K-Ras mutant lung cancer. Specifically, Runx3 gene-deleted, K-Ras gene-activated lung cancer mice established in the present invention were found to be completely cured without lung cancer recurrence likelihood when restoring the Runx3 gene, compared to the conventional approach of inhibiting the activated cancer gene. Thus, the composition comprising Runx3 protein, a polynucleotide coding therefor, a vector carrying the polynucleotide, or a vims or cell transformed with the vector as an active ingredient according to the present invention can be advantageously used as a composition for prevention or treatment of K-Ras mutant lung cancer.