치환된 스피로 유도체

• Main Authors: PANDE VINEET, LIU YINGTAO, QUEROLLE OLIVIER ALEXIS GEORGES, KRAMER CARSTEN SVEN, QIN LUOHENG, LI MING, ANGIBAUD PATRICK RENE, WU JIANPING, XU YANPING, PONCELET VIRGINIE SOPHIE, THURING JOHANNES WILHELMUS J, FANG LICHAO, LIU LIANZHU, DAI XUEDONG, COLOMBEL HELENE FRANCE SOLANGE, PILATTE ISABELLE NOELLE CONSTANCE, CAI WEI
• Format: Patent
• Language: Korean
• Published: 15.01.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 포유동물에서의 요법 및/또는 예방에 유용한 약제학적 제제, 그러한 화합물을 포함하는 약제학적 조성물, 및 암, 골수이형성 증후군(MDS) 및 당뇨병과 같은 질환을 치료하기에 유용한 메닌/MLL 단백질/단백질 상호작용 억제제로서의 이들의 용도에 관한 것이다. The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, pharmaceutical composition comprising such compounds, and their use as menin/MLL protein/protein interaction inhibitors, useful for treating diseases such as cancer, myelodysplastic syndrome (MDS) and diabetes.