E- HIGHLY POTENT MULTIMERIC E-SELECTIN ANTAGONISTS

• Main Authors: MAGNANI JOHN L, BAEK MYUNG GI, PETERSON JOHN M
• Format: Patent
• Language: English; Korean
• Published: 01.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 출원에는 E-셀렉틴 리간드에 대한 E-셀렉틴의 결합을 억제함으로써 적어도 하나의 질병, 질환, 및/또는 상태를 치료 및/또는 예방하기 위한 화합물, 조성물, 및 방법이 개시된다. 예를 들어, 매우 강력한 다량체성 E-셀렉틴 길항물질 및 적어도 1종의 동일물을 포함하는 약학 조성물이 개시된다. Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin to an E-selectin ligand are disclosed. For example, highly potent multimeric E-selectin antagonist are dessorbed and pharmaceutical compositions comprising at least one of the same.