항EGFR 항체의 방사성 복합체 및 방사성 의약
본 발명은, 약효를 손상시키는 일 없이 종래보다도 안정성이 높여진 복합체를 제공하는 것을 과제로 한다. 본 발명의 복합체는, 펩티드로 부위 특이적으로 수식된 항EGFR 항체와 킬레이트제의 복합체이며, 킬레이트제에 방사성 금속 핵종이 킬레이트화되어 있고, 펩티드와 킬레이트제가 링커(L)를 통해 연결되어 있고, 링커(L)는 티오우레아 결합을 포함하지 않는다. A conjugate having stability improved more than conventional conjugates without impairing the effica...
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| Main Authors | , , , |
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| Format | Patent |
| Language | Korean |
| Published |
30.11.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | 본 발명은, 약효를 손상시키는 일 없이 종래보다도 안정성이 높여진 복합체를 제공하는 것을 과제로 한다. 본 발명의 복합체는, 펩티드로 부위 특이적으로 수식된 항EGFR 항체와 킬레이트제의 복합체이며, 킬레이트제에 방사성 금속 핵종이 킬레이트화되어 있고, 펩티드와 킬레이트제가 링커(L)를 통해 연결되어 있고, 링커(L)는 티오우레아 결합을 포함하지 않는다.
A conjugate having stability improved more than conventional conjugates without impairing the efficacy is provided by the present invention. The conjugate of the present invention is a conjugate of an anti-EGFR antibody site-specifically modified with a peptide and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the peptide and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond. |
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| AbstractList | 본 발명은, 약효를 손상시키는 일 없이 종래보다도 안정성이 높여진 복합체를 제공하는 것을 과제로 한다. 본 발명의 복합체는, 펩티드로 부위 특이적으로 수식된 항EGFR 항체와 킬레이트제의 복합체이며, 킬레이트제에 방사성 금속 핵종이 킬레이트화되어 있고, 펩티드와 킬레이트제가 링커(L)를 통해 연결되어 있고, 링커(L)는 티오우레아 결합을 포함하지 않는다.
A conjugate having stability improved more than conventional conjugates without impairing the efficacy is provided by the present invention. The conjugate of the present invention is a conjugate of an anti-EGFR antibody site-specifically modified with a peptide and a chelating agent, wherein the chelating agent is chelated with a metal radionuclide, the peptide and the chelating agent are linked by a linker (L), and the linker (L) does not contain a thiourea bond. |
| Author | HANADA TAKAHISA TONOYA GOTA KAWATANI MINORU TAKEDA TAKUYA |
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| Snippet | 본 발명은, 약효를 손상시키는 일 없이 종래보다도 안정성이 높여진 복합체를 제공하는 것을 과제로 한다. 본 발명의 복합체는, 펩티드로 부위 특이적으로 수식된 항EGFR 항체와 킬레이트제의 복합체이며, 킬레이트제에 방사성 금속 핵종이 킬레이트화되어 있고, 펩티드와 킬레이트제가... |
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| Title | 항EGFR 항체의 방사성 복합체 및 방사성 의약 |
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