BCL의 결정성 고체 메글루민 염 억제제 및 이의 제조 방법 및 이의 사용 방법

• Main Authors: NING YUXI, LI JANE, LU YUE, LIAO LIANG, GUZ NATHAN, SHI ALBERT
• Format: Patent
• Language: Korean
• Published: 17.10.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

(R)-5-(4-클로로페닐)-1-이소프로필-2-메틸-4-(3-(4-(4-((4-((1-(페닐티오)-4-(4-((포스포노옥시)메틸)피페리딘-1-일)부탄-2-일)아미노)-3-((트리플루오로메틸)설포닐)페닐)설폰아미도)페닐)피페라진-1-일)페닐)-1H-피롤-3-카복실산의 결정성 고체 메글루민 염을 제공한다. 결정성 고체 메글루민 염 화합물 중 하나 이상을 갖는 제약학적 조성물 및 대상체에게 결정성 고체 메글루민 염 화합물을 투여하는 방법이 또한 기재되어 있다. 결정성 고체 메글루민 염 화합물을 제조하는 방법도 제공된다. Provided are the crystalline solid meglumine salts of (R)-5-(4-chlorophenyl)-1-isopropyl-2-methyl-4-(3-(4-(4-((4-((1-(phenylthio)-4-(4-((phosphonooxy)methyl)piperidin-1-yl)butan-2-yl)amino)-3- ((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl) piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid. Pharmaceutical compositions having one or more of the crystalline solid meglumine salt compounds and methods for administering the crystalline solid meglumine salt compounds to a subject are also described. Methods for preparing the crystalline solid meglumine salt compounds are also provided.