BIOMOLECULE CONJUGATES

• Main Authors: AUSTIN WESLEY, D'AGOSTINO LAURA AKULLIAN, CUERVO HERNAN, SCHWARTZ ERIC
• Format: Patent
• Language: English; Korean
• Published: 16.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 생체분자를 포함하는 생체분자 컨쥬게이트에 관한 것으로, 여기서 적어도 하나의 비-천연 아미노산(NNAA)이 생체분자의 구조에 필수적이며, NNAA는 페이로드, 특히 세포독성제가 부착되는 링커의 부착 지점이다. 보다 상세하게는, 본 발명은 세포결합제, 및 세포독성제를 포함하는 활성 방출 생성물의 컨쥬게이트에 관한 것으로, 컨쥬게이트는 고리첨가 반응에 의해 생성된다. 생성 방법, 약학적 조성물 및 사용 방법이 제공된다. The present invention relates to biomolecule conjugates which comprise a biomolecule wherein at least one non-natural amino acid (NNAA) is integral to the structure of the biomolecule and wherein the NNAA is a point of attachment of a linker to which a payload, particularly a cytotoxic agent, is attached. More specifically, this invention relates to conjugates of cell-binding agents and active release products comprising cytotoxic agents wherein the conjugates are produced by means of a cycloaddition reaction. Methods of production, pharmaceutical compositions and methods of use are provided.