ETHYL PIPERIDINE TRIAZOLO TRIAZINE DERIVATIVES THE SYNTHESIS METHOD THEREOF AND THE PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF CANCER CONTAINING THE SAME

• Main Authors: LEEJONGHYUN, CHOIJONGRYOUL, BYUNJOONSEOK, JUNGSEUNGHEE, LEE SEO JIN, KODONG HYUN, JANG HYU JEONG, AHN SANG YEOP, KIMJIWON, SON SEO HYUN, KIMSEOHYUN, DONGKYUKIM, KANG JI YOON, KIMDOYOUNG, KIM JI YONG, JISEUNGHEE
• Format: Patent
• Language: English; Korean
• Published: 11.10.2023
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

본 발명은 에틸 피페리딘 트리아졸로 트리아진 유도체, 이의 제조방법 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 상기 유도체는 아데노신 A2A 수용체(A2AR)에 길항제(antagonist)로 작용할 수 있어 다양한 A2AR 관련 질환, 특히 다양한 암의 예방 또는 치료에 효능을 나타낼 수 있고, 면역관문 억제제와 병용요법으로 사용될 경우 항암활성 측면에서 현저한 상승(synergy) 효과를 기대할 수 있다. The present invention relates to an ethyl piperidine triazolo triazine derivative, a synthesis method therefor, and a pharmaceutical composition including same for the prevention or treatment of cancer. Acting as an antagonist on an adenosine A2A receptor (A2AR), the derivative can exhibit efficacy for the prevention or treatment of various A2AR-related diseases, specifically, various cancers. When used in combination therapy with an immune checkpoint inhibitor, the derivative is expected to exhibit a remarkable synergistic effect in terms of anticancer activity.