PD-L1 OLIGONUCLEOTIDES FOR REDUCTION OF PD-L1 EXPRESSION

• Main Authors: OTTOSEN SOREN, LUANGSAY SOUPHALONE, JACKEROTT MALENE, JAVANBAKHT HASSAN, PEDERSEN LYKKE
• Format: Patent
• Language: English; Korean
• Published: 26.09.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 발명은 표적 세포에서 PD-L1의 발현을 감소시킬 수 있는 안티센스 올리고뉴클레오티드에 관한 것이다. 상기 올리고뉴클레오티드는 PD-L1 mRNA에 혼성화한다. 본 발명은 또한 올리고뉴클레오티드의 접합체, 및 약학 조성물, 및 상기 올리고뉴클레오티드를 사용하는, 바이러스성 간 감염, 예컨대 HBV, HCV 및 HDV; 기생충 감염, 예컨대 말라리아, 톡소플라즈마증, 리슈마니아증 및 트리파노소마증, 또는 간암 또는 간에서의 전이의 치료 방법에 관한 것이다. The present invention relates to antisense oligonucleotides that are capable of reducing expression of PD-L1 in a target cell. The oligonucleotides hybridize to PD-L1 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of viral liver infections such as HBV, HCV and HDV; a parasite infections such as malaria, toxoplasmosis, leishmaniasis and trypanosomiasis or liver cancer or metastases in the liver using the oligonucleotide.