Anti-Mesothelin Antibody and Antibody Drug Conjugate Thereof

• Main Authors: XU QIAOYU, FANG JIANMIN, LI SHENJUN, WANG MINGXUE, YE HUI, HUANG CHANGJIANG, LUO WENTING, JIANG JING
• Format: Patent
• Language: English; Korean
• Published: 22.09.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은 MSLN을 표적으로하는 항체 약물 컨쥬게이트(antibody drug conjugate, ADC)를 개시한다. 본 발명은 또한 항체 약물 컨쥬게이트(ADC)의 제조 방법을 개시한다. 본 발명은 또한 조작된(engineered) 중쇄 및 경쇄를 포함하는 신규한 MSLM 항체 또는 이의 기능성 단편을 개시한다. The present invention relates to a preparation process of an antibody drug conjugate intermediate. Compared with the prior art, according to the preparation process of the antibody drug conjugate intermediate provided in the present invention, because a drug part participates in the reaction in the last step, loss of the drug part, for example, a fed material such as MMAD/MMAE or MMAF, is reduced, production costs are reduced, and production benefits are increased. In addition, the process provided in the present invention is simple, environment-friendly, and suitable for industrial large-scale popularization.