DCLK1 Pharmaceutical composition for inhibiting cancer metastasis or recurrence comprising DCLK1 inhibitor

• Main Authors: LEE YUN HO, PARK SO YEON, KIM PIL HO, NAM JEONG SEOK
• Format: Patent
• Language: English; Korean
• Published: 29.08.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

One embodiment of the present invention provides a pharmaceutical composition for inhibiting cancer metastasis or recurrence comprising a DCLK1 phosphorylation activity inhibitor compound as an active ingredient. The DCLK1 phosphorylation activity inhibitor of the present invention binds to the kinase domain of DCLK1 overexpressed in cancer stem cells and inhibits phosphorylation, thereby inhibiting the proliferation and self-renewal of cancer stem cells, so that it is possible to be usefully used as an anticancer agent to inhibit cancer metastasis or recurrence. 본 발명의 일실시예는 DCLK1 인산화 활성 억제제 화합물을 유효성분으로 포함하는 암 전이 또는 재발 억제용 약학적 조성물을 제공한다. 본 발명의 DCLK1 인산화 활성 억제제는 암 줄기세포에 과발현하는 DCLK1의 키나아제 도메인에 결합하여 인산화를 억제함으로써 암 줄기세포의 증식과 자가재생을 억제하기 때문에 암의 전이 또는 재발을 억제하는 항암제로 유용하게 활용할 수 있다.