LCA 및 3-KCA를 UDCA 및 3-KUDCA로 전환하기 위한 효소적방법

• Main Authors: REID J. GREGORY, GREGORY MATT, PAUL BERNHARD J, SCHELL URSULA, REDDY JAYACHANDRA P
• Format: Patent
• Language: Korean
• Published: 04.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

7β-하이드록실화 시스템뿐만 아니라 이 시스템으로부터 리토콜산 및 3-케토-리토콜산의 7β-하이드록시 유도체를 생산하는 방법이 제공된다. 또한 상기 효소 시스템의 생산에 유용한 재조합 유기체 및 그러한 효소를 인코딩하는 플라스미드가 제공된다. 7β-hydroxylation systems are provided, as well as methods for producing ?P-hydroxy derivatives of lithocholic acid and 3-keto-lithocholic acid from such systems. Also provided are recombinant organisms useful for the production of such enzymatic systems, and to plasmids that encode for such enzymes.