Pharmaceutical composition for the prevention or treatment of nervous system diseases containing a herbal mixture containing Astragalus

• Main Authors: PARK SEONG IL, CHOI SEONG HWAN, YOO HO RYONG, KIM HYEONG GEUG
• Format: Patent
• Language: English; Korean
• Published: 20.07.2023
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a pharmaceutical composition for preventing or treating nervous system diseases, which contains, as an active ingredient, a mixture of Curcuma Longa Linne, Astragalus membranaceus Bunge, Brassica oleracea var. italica Plenck, Camellia sinensis (L.) O. Kuntze, Cirsium japonicum var. ussuriense Kitamura, and Piper nigrum. The present invention provides a pharmaceutical composition for preventing or treating nervous system diseases, which enables GR to attenuate neuronal apoptosis using HT-22 cells and to reduce both of NO and ROS in LPS-stimulated BV-2 cells in cell-based test tube experiments. Moreover, the pharmaceutical composition can rapidly protect against neuronal damage, especially inflammatory response and oxidation, in the hippocampal region of LPS-induced mouse brain tissue by inactivating a target to JNK and an upstream signaling pathway of MKK7 and pc-Jun to regulate Sestrin protein in an animal experiment. 본 발명은 강황(Curcuma Longa Linne), 황기(Astragalus membranaceus Bunge), 브로콜리(Brassica oleracea var. italica Plenck), 녹다엽(Camellia sinensis (L.) O. Kuntze), 엉겅퀴(Cirsium japonicum var. ussuriense Kitamura) 및 호초(Piper nigrum)의 혼합물을 유효성분으로 함유하는 신경계 질환의 예방 또는 치료용 약학적 조성물에 관한 것으로서, 본 발명의 신경계 질환의 예방 또는 치료용 약학적 조성물은 세포 기반 시험관 실험에서 GR은 HT-22 세포를 사용하여 신경 세포 사멸을 약화시키고 LPS로 자극된 BV-2 세포에서 NO와 ROS를 모두 감소시킬 수 있다. 또한, 동물 실험에서 JNK에 대한 표적과 MKK7 및 pc-Jun의 상류 신호 전달 경로를 비활성화하여 Sestrin 단백질을 조절함으로써 LPS 유도 마우스 뇌 조직의 해마 영역에서 신경 손상, 특히 염증 반응 및 산화를 신속하게 보호할 수 있다.