낭성 섬유증 막관통 전도도 조절자의 조절제

• Main Authors: HADIDA RUAH SARA SABINA, PIERRE FABRICE, MCCARTNEY JASON, DWIGHT TIMOTHY A, PARASELLI PRASUNA, KHATUYA HARIPADA, UY JOHNNY, FANNING LEV TYLER DEWEY, SILINA ALINA, ARUMUGAM VIJAYALAKSMI, GROOTENHUIS PETER, ANDERSON COREY DON, COON TIMOTHY RICHARD, FRIEMAN BRYAN A, GULEVICH ANTON V, ZHOU JINGLAN, VALDEZ LINO, ABRAHAM SUNNY, MELILLO VITO, TRAN JOE A, CHAU JACLYN, CLEVELAND THOMAS, ABELA ALEXANDER RUSSELL, MILLER MARK THOMAS, CLEMENS JEREMY, KRENITSKY PAUL, ISHIHARA YOSHIHIRO
• Format: Patent
• Language: Korean
• Published: 10.07.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 개시는 코어 구조를 갖는 낭포성 섬유증 막관통 전도도 조절자(CFTR)의 조절제: JPEGpct00625.jpg4878 적어도 하나의 이러한 조절제를 함유하는 약학적 조성물; 이러한 조절제 및 약학적 조성물을 사용해 낭성 섬유증을 포함하는 CFTR 매개 질환을 치료하는 방법; 병용 약학적 조성물 및 병용 요법; 및 이러한 조절제를 제조하기 위한 프로세스 및 중간체를 제공한다. This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.