TRICYCLIC DERIVATIVE COMPOUNDS AND USE THEREOF

• Main Authors: YOON MIJA, LEE DOHYUNG, KANG SEUNGHEE, KIM MISUN, LEE SANGHAK
• Format: Patent
• Language: English; Korean
• Published: 07.07.2023
• Subjects: CHEMISTRY; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a novel tricyclic derivative compound or a pharmaceutically acceptable salt thereof and uses thereof. Since the novel tricyclic derivative compound has excellent STAT3 inhibitory activity and exhibits a superior inhibitory effect than known compounds currently in phase 3 clinical trials, thereby being able to be used as a treatment for STAT3-related diseases. 본 발명은 신규 트리사이클릭 유도체 화합물 또는 이의 약제학적으로 허용 가능한 염 및 이의 용도에 관한 것으로, 우수한 STAT3 저해 활성을 갖는 것으로, 현재 임상 3상 진행중인 공지 화합물보다 우수한 억제효과를 나타내는 것으로 확인되어, STAT3 관련 질환의 치료제로 사용될 수 있다.