Pharmaceutical Composition for Preventing or Treating Cancer Comprising Carnitine Acylcarnitine Carrier Inhibitor and Peroxisomal Beta Oxidation Inhibitor

• Main Author: KIM SOO YOUL
• Format: Patent
• Language: English; Korean
• Published: 05.07.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising a carnitine acylcarnitine carrier (CAC) inhibitor and a peroxisomal beta oxidation inhibitor. In the present invention, it was confirmed that co-administration of the CAC inhibitor and the peroxisomal beta oxidation inhibitor significantly reduced the growth of cancer cells compared to administration of the inhibitors individually, and anticancer synergy effects according to co-administration are exhibited. Accordingly, the composition comprising the CAC inhibitor and the peroxisomal beta oxidation inhibitor, of the present invention, can be provided as an effective anticancer drug for combination therapy. 본 발명은 카르니틴 아실카르니틴 운반자(Carnitine Acylcarnitine Carrier: CAC) 억제제 및 퍼옥시좀 베타 산화 억제제(Peroxisomal Beta Oxidation Inhibitor)를 포함하는 암 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에서는 카르니틴 아실카르니틴 운반자 억제제 및 퍼옥시좀 베타 산화 억제제를 병용투여 하는 경우 약물을 각각 단독으로 사용하는 경우에 비하여 암세포 성장을 유의적으로 감소시켰을 뿐만 아니라, 병용투여에 따른 항암 시너지 효과를 확인하였다. 따라서, 본 발명의 카르니틴 아실카르니틴 운반자 억제제 및 퍼옥시좀 베타 산화 억제제를 포함하는 조성물은 효과적인 병용 항암제로서 제공될 수 있다.