복제 스트레스 경로 제제 조성물 및 암의 치료 방법

• Main Authors: CHRISTIANSEN JASON, HANSEN RYAN, HASSIG CHRISTIAN, HORNBY ZACHARY, CHOWDHRY SUDHIR, MILUTINOVIC SNEZANA, WILKINSON DEEPTI, CELESTE ANTHONY, TURNER KRISTEN
• Format: Patent
• Language: Korean
• Published: 03.07.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

대상체에서 암을 치료하는 방법이 본원에 제공되며, 여기서 상기 암은 염색체외 DNA 양성(ecDNA 양성)이거나 치료적으로 내성이며, 상기 방법은 대상체에게 치료적 유효량의 복제 스트레스(RS) 경로 제제를 단독으로 또는 표적화 치료제와 병용하여 투여하는 단계를 포함한다. Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.