건강 상태를 진단 또는 치료하거나 CAR-T 세포 요법의 치료 효능을 최적화하기 위한 방법

• Main Authors: MONJE DEISSEROTH MICHELLE, MACKALL CRYSTAL L, ALIZADEH ARASH ASH, MAJZNER ROBBIE, SWORDER BRIAN, KURTZ DAVID M, NATKUNAM YASODHA, MOUNT CHRISTOPHER, MIKLOS DAVID B, FRANK MATTHEW
• Format: Patent
• Language: Korean
• Published: 22.06.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

본 개시는 일반적으로, 특히, CD58 발현의 수준 감소 또는 손실 또는 CD58 활성에서 분자 변경과 관련된 다양한 건강 상태, 예를 들어, 증식성 장애(예를 들어, 암)를 진단 및/또는 치료하기 위한 방법, 키트 및 시스템에 관한 것이다. The present disclosure generally relates to, inter alia, methods, kits, and systems for the diagnosis and/or treating various health conditions, such as proliferative disorders (e.g., cancers), associated with a decreased level or a loss of CD58 expression or molecular alterations in CD58 activity.