METHOD FOR PRODUCING A GLYCINAMIDE COMPOUND

• Main Authors: NAITO HIROYUKI, ASHIDA SHINJI, YOSHIDA MASAO, ABE YUKI, MORITA KOJI, MIYAZAKI HIDEKI, NAKADA TAKASHI, KASUYA YUJI, OGITANI YUSUKE, MASUDA TAKESHI
• Format: Patent
• Language: English; Korean
• Published: 15.06.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

항종양 효과와 안전성면이 우수한 항종양약으로서, 다음 식으로 나타내는 항종양성 화합물과 항체를, 다음 식 ： -L1-L2-LP-NH-(CH2)n1-La-Lb-Lc- 로 나타내는 구조의 링커를 개재하여 결합시킨 것을 특징으로 하는 항체-약물 콘주게이트 (항체는 L1 의 말단에 있어서 결합하고, 항종양성 화합물은 1 위치의 아미노기의 질소 원자를 결합 부위로서, Lc 의 말단에 있어서 결합한다) 를 제공한다. TIFFpat00261.tif5267 As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-B7-H3 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH-(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lcwith the nitrogen atom of the amino group at position 1 as a connecting position.