Compositions for anti-inflammatory anti-allergy or strengthening skin barrier comprising extracts of Parasenecio auriculatus var. matsumurana Nakai

• Main Authors: KIM WON KYU, HWANG HO SEONG, BAEK JONG GWON, LEE SOON KWANG, JUNG SANG HOON, CHO SU YEON, KWON HAK CHEOL, LEE WOOK BIN, KANG YOON JIN, LEE SEUNG JIN, KWON YU JIN, KWON JAE YOUNG
• Format: Patent
• Language: English; Korean
• Published: 08.06.2023
• Subjects: FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for the treatment, improvement, or prevention of anti-inflammatory, anti-allergic, skin barrier strengthening, or atopic dermatitis, comprising a Parasenecio auriculatus extract or a fraction thereof as an active ingredient. According to one aspect, the Parasenecio auriculatus extract has excellent anti-inflammatory, anti-allergy, and atopic dermatitis treatment effects, including suppressing degranulation of mast cells or basophils, suppressing the expression level of cytokines, and exhibiting excellent efficacy in atopic animal models. Therefore, a highly effective therapeutic agent can be developed using the extract as an active ingredient. In addition, the Parasenecio auriculatus extract has excellent efficacy in strengthening the skin barrier and improving skin elasticity not only to improve skin aging but also to be effective in treating atopic dermatitis. 본 발명은 박쥐나물 (Parasenecio auriculatus var. matsumurana Nakai) 추출물 또는 이의 분획물을 유효성분으로 포함하는, 항염증, 항알러지, 피부 장벽 강화 또는 아토피성 피부염 치료, 개선 또는 예방용 조성물에 관한 것이다. 일 양상에 따르면 따르면, 박쥐나물 추출물은 비만세포 또는 호염기구의 탈과립을 억제하고, 사이토카인의 발현 수준을 억제하며, 아토피 동물 모델에서 우수한 효능을 나타내는 등 항염증, 항알러지 및 아토피 피부염 치료 효과가 우수한 바, 상기 추출물을 유효성분으로 하여 효과가 우수한 치료제를 개발할 수 있다. 또한, 상기 박쥐나물 추출물은 피부 장벽 강화 및 피부 탄력 개선 효능이 우수한 바, 피부 노화를 개선할 수 있을 뿐만 아니라, 아토피 피부염 치료에도 효능을 나타낼 수 있다.