PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

• Main Authors: FROST JENNIFER M, ECONOMOU CHRISTOS, ZHANG QINGWEI I, FOSU STACY, SHIROODI REZA, O'CONNOR MATTHEW, BAUMGARTNER CHRISTINA, FARNEY ELLIOT P, KYM PHILIP R, MATULENKO MARK A, VOIGHT ERIC, HALVORSEN GEOFF T, BOGDAN ANDREW, ABBOTT JASON, XIONG ZHAOMING
• Format: Patent
• Language: English; Korean
• Published: 31.05.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

단백질 티로신 포스파타제, 예를 들어 단백질 티로신 포스파타제 비-수용체 유형 2(PTPN2) 및/또는 단백질 티로신 포스파타제 비-수용체 유형 1(PTPN1)을 억제하고, PTPN1 또는 PTPN2 억제제 치료에 유리하게 반응성인 관련된 질환, 장애 및 병태, 예를 들어 암 또는 대사 질환을 치료하는데 유용한 화합물, 조성물 및 방법이 본 명세서에 제공된다. Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.