Composition comprising component derived from induced pluripotent stem cell culture medium and uses thereof

• Main Authors: DOOYOUNG CHOI, JI HYEON JU, JURYUN KIM, YOOJUN NAM
• Format: Patent
• Language: English; Korean
• Published: 10.04.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a composition for preventing, improving or treating nerve cell damage diseases containing components derived from the supernatant of induced pluripotent stem cell (iPSC) culture medium. Exosomes of the present invention are separated from the culture medium of iPSC and can alleviate nerve cell damage or regenerate the skin, so that it is possible to be effectively used as a composition for preventing, alleviating or treating diseases related to nerve cell damage, especially loss of taste or smell due to coronavirus infection or Alzheimer's disease, or a composition for skin regeneration. 본 발명은 유도만능줄기세포(induced pluripotent stem cell; iPSC) 배양 배지의 상층액 유래 성분을 포함하는 신경세포 손상 질환의 예방, 개선 또는 치료용 조성물에 대한 것이다. 본 발명의 엑소좀은 유도만능줄기세포로의 배양 배지에서 분리되어 신경세포 손상을 개선 내지 피부를 재생시킬 수 있으므로 신경세포 손상 관련 질환, 특히 코로나 바이러스 감염으로 인한 미각 내지 후각이상이나 알츠하이머 질환의 예방, 개선 또는 치료용 조성물 내지 피부 재생용 조성물로서 효과적으로 사용될 수 있다.