Pharmaceutical composition for preventing or treating cancer comprising omeprazole browning matter

• Main Author: KIM SOO YOUL
• Format: Patent
• Language: English; Korean
• Published: 30.03.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for preventing or treating cancer, and an anticancer adjuvant, containing browned material of omeprazole (KN510). In the present invention, conventional omeprazole is treated with an acid to prepare browned material (acid decomposition product) of omeprazole, and a pancreatic cancer cell line was treated with the prepared browned material (acid decomposition product) of omeprazole, which demonstrated a significant increase in anticancer effect compared to the conventional omeprazole. Therefore, the browned material (acid decomposition product) of omeprazole (KN510) of the present invention can be used in a composition for preventing or treating cancer or an anticancer adjuvant. 본 발명은 오메프라졸(KN510) 갈변물질을 포함하는 암 예방 또는 치료용 약학적 조성물, 및 항암보조제에 관한 것이다. 본 발명에서는 기존 오메프라졸에 산을 처리하여 오메프라졸 갈변물질(산분해물)을 제조하였으며, 제조된 오메프라졸 갈변물질(산분해물)을 췌장암 세포주에 처리한 결과, 기존 오메프라졸에 비해 항암효과가 현저하게 증가하는 것을 확인하였다. 따라서, 본 발명의 오메프라졸(KN510) 갈변물질(산분해물)은 암 예방 또는 치료용 조성물, 또는 항암 보조제로 활용될 수 있다.