The Functional food components for the prevention and improvement of lung diseases caused by fine dust containing Namcheon leaf extracts as valid ingredients

• Main Authors: MI YOUNG YUN, HWA JUNG CHOI, JUNG WON KIM
• Format: Patent
• Language: English; Korean
• Published: 08.03.2023
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a functional food composition comprising a Nandina domestica Thunb leaf extract as an active ingredient to prevent and ameliorate pulmonary disease caused by fine dust, and more specifically, to a functional food composition comprising 0.1 - 10 wt% of a Nandina domestica Thunb leaf extract as an active ingredient to prevent and ameliorate pulmonary disease caused by fine dust. According to the present invention, the Nandina domestica Thunb leaf extract can reduce histological changes in lung tissue, including intravenous immunoglobulin, inflammatory cell infiltration, and cell proliferation, can inhibit the activity of inflammatory cytokines, such as IL-17, TNF-α, MIP-2, and CXCL-1, and is a natural extract and thus does not cause toxicity or side effects when used as a raw material for a health functional food composition and can be taken for a long term. 본 발명은 남천 잎 추출물을 유효성분으로 함유하는 미세먼지로 인한 폐질환 예방 및 개선용 기능성 식품 조성물에 관한 것으로서, 더 상세하게는, 남천 잎 추출물 0.1~10중량%를 유효성분으로 함유하는 미세먼지로 인한 폐질환 예방 및 개선용 기능성 식품 조성물에 관한 것이다. 본 발명에 따르면, 호중구 수, 염증세포 침윤 및 세포증식을 포함한 폐 조직의 조직학적 변화를 감소시키고, IL-17, TNF-α, MIP-2 및 CXCL-1인 염증성 사이토카인(cytokine)의 활성을 억제할 뿐 아니라, 천연물 추출물로서 건강기능성 식품 조성물의 원료로 사용될 경우 독성과 부작용이 없으며, 장기적으로 복용 가능한 남천 잎 추출물을 유효성분으로 함유하는 미세먼지로 인한 폐질환 예방 및 개선용 기능성 식품 조성물로 유용하게 활용될 수 있는 효과가 있다.