Vector for delivering an active substance to the nervous system and its use

• Main Authors: HAM SANGWOO, KIM YUNHA, LEE DONGSOO, CHO GYU BON, JANG JAE HYUNG, LEE JAE YOUNG, BAE HEE SOOK
• Format: Patent
• Language: English; Korean
• Published: 07.03.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present application relates to a vector for delivering active substances to the nervous system. In one embodiment of the present application, a vector for delivering an active material in which one or more TTR ligands are conjugated to the surface of an adeno-associated virus is provided. The active material delivery vector provided by the present application can be delivered to the nervous system when administered in cerebrospinal fluid. 본 출원은 신경계로의 활성물질 전달을 위한 활성물질 전달용 벡터에 관한 것이다. 본 출원의 일 실시양태로, 하나 이상의 TTR 리간드가 아데노연관바이러스의 표면에 컨쥬게이트된 활성물질 전달용 벡터가 제공된다.