MSH2 Composition comprising a MSH2 inhibitor for preventing or treating cancer

• Main Authors: NA MIN JEONG, NAM SUK WOO
• Format: Patent
• Language: English; Korean
• Published: 16.02.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a composition for preventing or treating cancer, comprising an MSH2 inhibitor as an active ingredient. The MSH2 inhibitor according to the present invention was confirmed to: inhibit tumor cell growth and proliferation in various carcinoma cells, including hepatocellular carcinoma, and in particular, inhibit migration, invasion, and tumorigenic activity in hepatocellular carcinoma; and increase DNMT1 expression and reduce KLF4 expression, when MSH2 expression is increased, and thus can be used as a pharmaceutical composition for the prevention and treatment of cancer. 본 발명은 MSH2 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 MSH2 억제제는 간세포암종를 포함한 다양한 암종 세포에서 종양 세포 성장, 증식을 억제하였고, 특히 간세포암종에서는 이동 및 침습, 종양 형성 활성을 억제하고, MSH2의 발현을 증가시키는 경우 DNMT1의 발현을 증가시키고, KLF4의 발현을 감소시키는 것을 확인함으로써, 이를 암의 예방 및 치료용 약학적 조성물로 이용할 수 있다.