MSH2 Composition comprising a MSH2 inhibitor for preventing or treating cancer
The present invention relates to a composition for preventing or treating cancer, comprising an MSH2 inhibitor as an active ingredient. The MSH2 inhibitor according to the present invention was confirmed to: inhibit tumor cell growth and proliferation in various carcinoma cells, including hepatocell...
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Main Authors | , |
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Format | Patent |
Language | English Korean |
Published |
16.02.2023
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a composition for preventing or treating cancer, comprising an MSH2 inhibitor as an active ingredient. The MSH2 inhibitor according to the present invention was confirmed to: inhibit tumor cell growth and proliferation in various carcinoma cells, including hepatocellular carcinoma, and in particular, inhibit migration, invasion, and tumorigenic activity in hepatocellular carcinoma; and increase DNMT1 expression and reduce KLF4 expression, when MSH2 expression is increased, and thus can be used as a pharmaceutical composition for the prevention and treatment of cancer.
본 발명은 MSH2 억제제를 유효성분으로 포함하는 암 예방 또는 치료용 조성물에 관한 것으로, 본 발명에 따른 MSH2 억제제는 간세포암종를 포함한 다양한 암종 세포에서 종양 세포 성장, 증식을 억제하였고, 특히 간세포암종에서는 이동 및 침습, 종양 형성 활성을 억제하고, MSH2의 발현을 증가시키는 경우 DNMT1의 발현을 증가시키고, KLF4의 발현을 감소시키는 것을 확인함으로써, 이를 암의 예방 및 치료용 약학적 조성물로 이용할 수 있다. |
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Bibliography: | Application Number: KR20220070947 |