보론산 유도체 및 합성, 다형체 형태, 그리고 이들의 치료적 용도

• Main Authors: HECKER SCOTT J, LINDER THOMAS, LEFORT LAURENT, BIO MATTHEW M, ZHU ZUOLIN, BOYER SERGE HENRI, GONZALES DE CASTRO ANGELA, FANG YUANQING
• Format: Patent
• Language: Korean
• Published: 10.02.2023
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

본 명세서에는 항균성 화합물, 다형체 형태, 조성물, 약제학적 조성물, 이들의 제조 및 사용 방법이 기재되어 있다. 일부 실시형태는 보론산 유도체 및 치료제, 예를 들어, β-락타마제 저해제(BLI)로서의 이의 용도에 관한 것이다. Disclosed herein are antimicrobial compounds, polymorphic forms, compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).